College football betting lines: Michigan heads to Oklahoma in ranked showdown

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  • ESPN

Sep 2, 2025, 05:00 PM ET

The first full weekend of college football action saw three top-10 teams fall, as well as Florida State upset Alabama as 13.5-point underdogs. The Seminoles rose the highest in this week's rankings, settling in at No. 14. Alabama, ranked in their 280th consecutive AP Poll, fall to No. 21.

There is only one matchup between two ranked teams in Week 2, as No. 15 Michigan head to Norman for a showdown with No. 18 Oklahoma. Michigan defeated New Mexico 34-17 in Ann Arbor, while Oklahoma routed Illinois State 35-3 as QB John Mateer threw for 392 yards and Keontez Lewis hauled in two touchdowns.

Only four conferences -- the Big Ten, ACC, Big 12 and SEC -- as well as independent Notre Dame, are represented in this week's poll, making this the second time in 55 years that four or fewer conferences are represented, according to ESPN Research.

The action starts Saturday at noon ET on ABC with San Jose State Spartans taking on Arch Manning and No. 7 Texas Longhorns in Austin. Here's where you can find where to watch every game.

Here are the available betting lines for all Week 2 games featuring top-25 preseason ranked teams.

All times Eastern. For latest lines, go to ESPN BET

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Florida International at No. 2 Penn State -43.5
Saturday, Noon, BTN

Records: Florida International 2-0, 0-0 vs. AP teams; Penn State 1-0, 0-0 vs. AP teams
Opening Line: Penn State -43.5, O/U 54.5
Money line: Off
Over/Under: 54.5 (O -110, U 110)

FPI Projection Penn State by 33 points, 98% probability to win game


San José State at No. 7 Texas -36.5
Saturday, Noon, ABC

Records: San José State 0-1, 0-0 vs. AP teams; Texas 0-1, 0-1 vs. AP teams
Opening Line: Texas -36.5, O/U 51.5
Money line: Off
Over/Under: 51.5 (O -115, U 105)

FPI Projection Texas by 37 points, 99% probability to win game


No. 11 Illinois -2.5 at Duke
Saturday, Noon, ESPN

Records: Illinois 1-0, 0-0 vs. AP teams; Duke 1-0, 0-0 vs. AP teams
Opening Line: Illinois -2.5, O/U 50.5
Money line: Illinois (-130); Duke (+110)
Over/Under: 50.5 (O EVEN, U 120)

FPI Projection Duke by 0.1 points, 51% probability to win game


East Texas A&M at No. 14 Florida State
Saturday, Noon, ACC Network

Records: East Texas A&M 1-0; Florida State 1-0, 1-0 vs. AP teams

No line posted

FPI Projection Florida State by 35.5 points, 99% probability to win game


Iowa at No. 16 Iowa State -3.5
Saturday, Noon, FOX

Records: Iowa 1-0, 0-0 vs. AP teams; Iowa State 2-0, 1-0 vs. AP teams
Opening Line: Iowa State -3.5, O/U 41.5
Money line: Iowa (+110); Iowa State (-130)
Over/Under: 41.5 (O -110, U -110)

FPI Projection Iowa State by 3.8 points, 65% probability to win game


Baylor at No. 17 SMU -3
Saturday, Noon, The CW Network

Records: Baylor 0-1, 0-0 vs. AP teams; SMU 1-0, 0-0 vs. AP teams
Opening Line: SMU -3, O/U 65.5
Money line: Baylor (+115); SMU (-135)
Over/Under: 65.5 (O -105, U -115)

FPI Projection SMU by 4.5 points, 67% probability to win game


Kennesaw State at No. 23 Indiana -34.5
Saturday, Noon, FS1

Records: Kennesaw State 1-0, 0-0 vs. AP teams; Indiana 1-0, 0-0 vs. AP teams
Opening Line: Indiana -34.5, O/U 50.5
Money line: Off
Over/Under: 50.5 (O -110, U -110)

FPI Projection Indiana by 23 points, 95% probability to win game


Kent State at No. 24 Texas Tech -48.5
Saturday, Noon, TNT, truTV

Records: Kent State 1-0, 0-0 vs. AP teams; Texas Tech 1-0, 0-0 vs. AP teams
Opening Line: Texas Tech -48.5, O/U 58.5
Money line: Off
Over/Under: 58.5 (O -110, U -110)

FPI Projection Texas Tech by 33.3 points, 98% probability to win game


Utah State at No. 19 Texas A&M -29.5
Saturday, 12:45 p.m., SEC Network

Records: Utah State 1-0, 0-0 vs. AP teams; Texas A&M 1-0, 0-0 vs. AP teams
Opening Line: Texas A&M -29.5, O/U 54.5
Money line: Off
Over/Under: 54.5 (O -105, U -115)

FPI Projection Texas A&M by 26.5 points, 96% probability to win game


Grambling at No. 1 Ohio State
Saturday, 3:30 p.m., BTN

Records: Grambling 1-0; Ohio State 1-0, 1-0 vs. AP teams

No line posted

FPI Projection Ohio State by 58.6 points, >99% probability to win game


Austin Peay at No. 4 Georgia
Saturday, 3:30 p.m., ESPN+, SECN+

Records: Austin Peay 1-0; Georgia 1-0, 0-0 vs. AP teams

No line posted

FPI Projection Georgia by 44.1 points, >99% probability to win game


Oklahoma State at No. 6 Oregon -28.5
Saturday, 3:30 p.m., CBS, Paramount+

Records: Oklahoma State 1-0, 0-0 vs. AP teams; Oregon 1-0, 0-0 vs. AP teams
Opening Line: Oregon -28.5, O/U 58.5
Money line: Off
Over/Under: 58.5 (O -115, U -105)

FPI Projection Oregon by 20.8 points, 93% probability to win game


Troy at No. 8 Clemson -33.5
Saturday, 3:30 p.m., ACC Network

Records: Troy 1-0, 0-0 vs. AP teams; Clemson 0-1, 0-1 vs. AP teams
Opening Line: Clemson -33.5, O/U 52.5
Money line: Off
Over/Under: 52.5 (O -105, U -115)

FPI Projection Clemson by 19.4 points, 92% probability to win game


No. 20 Ole Miss -10.5 at Kentucky
Saturday, 3:30 p.m., ABC

Records: Ole Miss 1-0, 0-0 vs. AP teams; Kentucky 1-0, 0-0 vs. AP teams
Opening Line: Ole Miss -10.5, O/U 52.5
Money line: Ole Miss (-400); Kentucky (+300)
Over/Under: 52.5 (O -105, U -115)

FPI Projection Ole Miss by 11.5 points, 84% probability to win game


East Tennessee State at No. 22 Tennessee
Saturday, 3:30 p.m., ESPN+, SECN+

Records: East Tennessee State 1-0; Tennessee 1-0, 0-0 vs. AP teams

No line posted

FPI Projection Tennessee by 40.7 points, >99% probability to win game


South Florida at No. 13 Florida -17.5
Saturday, 4:15 p.m., SEC Network

Records: South Florida 1-0, 1-0 vs. AP teams; Florida 1-0, 0-0 vs. AP teams
Opening Line: Florida -17.5, O/U 54.5
Money line: South Florida (+550); Florida (-900)
Over/Under: 54.5 (O -105, U -115)

FPI Projection Florida by 10.8 points, 83% probability to win game


Cal Poly at No. 25 Utah
Saturday, 6 p.m., ESPN+

Records: Cal Poly 1-0; Utah 1-0, 0-0 vs. AP teams

No line posted

FPI Projection Utah by 46.6 points, 100% probability to win game


Bethune-Cookman at No. 5 Miami
Saturday, 7 p.m., ESPN+, ACC Extra

Records: Bethune-Cookman 0-1; Miami 1-0, 1-0 vs. AP teams

No line posted

FPI Projection Miami by 57.6 points, 100% probability to win game


South Carolina State at No. 10 South Carolina
Saturday, 7 p.m., ESPN+, SECN+

Records: South Carolina State 1-0; South Carolina 1-0, 0-0 vs. AP teams

No line posted

FPI Projection South Carolina by 44.6 points, 99% probability to win game


Louisiana Tech at No. 3 LSU -37.5
Saturday, 7:30 p.m., ESPN+, SECN+

Records: Louisiana Tech 1-0, 0-0 vs. AP teams; LSU 1-0, 1-0 vs. AP teams
Opening Line: LSU -37.5, O/U 51.5
Money line: Off
Over/Under: 51.5 (O -105, U -115)

FPI Projection LSU by 29.5 points, 97% probability to win game


No. 12 Arizona State -6.5 at Mississippi State
Saturday, 7:30 p.m., ESPN2

Records: Arizona State 1-0, 0-0 vs. AP teams; Mississippi State 1-0, 0-0 vs. AP teams
Opening Line: Arizona State -6.5, O/U 59.5
Money line: Arizona State (-225); Mississippi State (+190)
Over/Under: 59.5 (O -105, U -115)

FPI Projection Arizona State by 1 points, 54% probability to win game


No. 15 Michigan at No. 18 Oklahoma -5.5
Saturday, 7:30 p.m., ABC

Records: Michigan 1-0, 0-0 vs. AP teams; Oklahoma 1-0, 0-0 vs. AP teams
Opening Line: Oklahoma -5.5, O/U 45.5
Money line: Michigan (+115); Oklahoma (-135)
Over/Under: 45.5 (O -115, U -105)

FPI Projection Oklahoma by 0.9 points, 54% probability to win game


UL Monroe at No. 21 Alabama -36.5
Saturday, 7:45 p.m., SEC Network

Records: UL Monroe 1-0, 0-0 vs. AP teams; Alabama 0-1, 0-0 vs. AP teams
Opening Line: Alabama -36.5, O/U 50.5
Money line: Off
Over/Under: 50.5 (O -115, U -105)

FPI Projection Alabama by 26.6 points, 96% probability to win game

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